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Synfacts 2011(5): 0508-0508  
DOI: 10.1055/s-0030-1259868
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Sulfinylimines

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
D. Guijarro*, Ó. Pablo, M. Yus*
Universidad de Alicante, Spain
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

Achiral β-amino alcohols were used as ligands in the ruthenium-catalyzed asymmetric transfer hydrogenation of sulfinylimines. Using both sulfinylimine enantiomers, the authors found that chirality was retained, suggesting the diastereoselectivity is controlled by the sulfinyl group, not the alcohol ligand.