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Synfacts 2011(8): 0916-0916  
DOI: 10.1055/s-0030-1260708
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Magnetic Nanoparticle Supported Osmium for Olefin Dihydroxylation

Contributor(s): Yasuhiro Uozumi, Noboru Kobayashi
K. Fujita*, S. Umeki, M. Yamazaki, T. Ainoya, T. Tsuchimoto, H. Yasuda
National Institute of Advanced Industrial Science and Technology, Tsukuba and Meiji University, Kawasaki, Japan
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Publikationsdatum:
20. Juli 2011 (online)

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Significance

Magnetic nanoparticle supported dendric composites 4[Gn] with OsO4 ²- as counter anion were prepared according to eq. 1. The osmium composites 4[G2] catalyzed the dihydrox­ylation of olefins 5 with NMO in acetone-H2O (2:1, v/v) to afford the corresponding diols 6 in up to 97% yield (eq. 2, 10 examples). After the dihydroxylation of β-methylstyrene (5a), the catalyst was recovered by magnetic separation and reused four times (6a, 4th reuse: 96% yield).