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DOI: 10.1055/s-0031-1280269
© Georg Thieme Verlag KG Stuttgart · New York
Influence of Co-Administered Danshensu on Pharmacokinetic Fate and Tissue Distribution of Paeonol in Rats
Publication History
received August 16, 2011
revised Sept. 13, 2011
accepted Sept. 15, 2011
Publication Date:
06 October 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201202/lookinside/thumbnails/10.1055-s-0031-1280269-1.jpg)
Abstract
Cortex Moutan (root bark of Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae (root and rhizome of Salvia miltiorrhiza Bunge) are two herbs widely used in traditional Chinese medicine (TCM) to treat cerebrovascular and cardiovascular diseases. In clinical practice, these two herbs are prescribed together. Studies on the pharmacokinetic interaction between the active constituents of these two herbs (paeonol and danshensu, respectively) can provide substantial foundation for understanding its mechanism and empirical evidence to support the clinical practice. A simple and sensitive high-performance liquid chromatographic (HPLC) method coupled with ultraviolet detector was developed for determination of paeonol in plasma and different tissues (heart, liver, spleen, lung, kidney, and brain) of male Sprague-Dawley rats. When co-administering danshensu, the peak plasma concentration of paeonol was decreased (p < 0.01), the mean residence time (MRT) was prolonged (p < 0.001), the volume of distribution (Vd/F) was increased (p < 0.001), and the concentrations of paeonol in heart, brain, and lung were dramatically increased (p < 0.01 or p < 0.001), compared with these values for rats administered paeonol alone. The results showed that the co-administration of danshensu could alter pharmacokinetic fate and tissue distribution of paeonol in rats, especially in heart and brain, providing substantial foundation for the investigation of the impact of danshensu on paeonol in clinical applications.
Key words
paeonol - Danshensu - HPLC - pharmacokinetics - tissue distribution - pharmacokinetic interaction
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Prof. Siwang Wang
Institute of Materia Medica, School of Pharmacy
Fourth Military Medical University
169 West Changle Road
710032 Xi'an
People's Republic of China
Phone: +86 29 8477 47 48
Fax: +86 29 8322 47 90
Email: wangsiw@hotmail.com
Associate Prof. Bangle Zhang
Department of Pharmaceutics, School of Pharmacy
Fourth Military Medical University
169 West Changle Road
710032 Xi'an
People's Republic of China
Phone: +86 29 8477 45 56
Fax: +86 29 8477 45 52
Email: blezhang@hotmail.com