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DOI: 10.1055/s-0031-1280292
© Georg Thieme Verlag KG Stuttgart · New York
Morning Glory Resin Glycosides as Modulators of Antibiotic Activity in Multidrug-Resistant Gram-Negative Bacteria
Publication History
received August 24, 2011
revised September 19, 2011
accepted September 21, 2011
Publication Date:
14 October 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201202/lookinside/thumbnails/10.1055-s-0031-1280292-1.jpg)
Abstract
Twenty-six microbiologically inactive (MIC > 512 µg/mL) convolvulaceous resin glycosides (1–26) were tested for resistance modulatory activity in vitro against Escherichia coli Rosetta-gami and two nosocomial pathogens, Salmonella typhi and Shigella flexneri. These compounds exerted a potentiation effect of the clinically useful antibiotics tetracycline, kanamycin, and chloramphenicol against the tested gram-negative bacteria by increasing antibiotic susceptibility up to 32-fold at concentrations of 25 µg/mL. Therefore, the oligosaccharides from the morning glory family (Convolvulaceae) represent metabolites that reverse microbial resistance mechanisms, favoring an increase in the strength and effectiveness of current antibiotics that are not effective in the treatment of refractive infections caused by multidrug-resistant strains.
Key words
resin glycosides - Convolvulaceae - Escherichia coli Rosetta-gami - Shigella flexneri - Salmonella typhi - multidrug resistance
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Dr. Rogelio Pereda-Miranda
Departamento de Farmacia, Facultad de Química
Universidad Nacional Autónoma de México
Ciudad Universitaria
Mexico City 04510 DF
Mexico
Phone: +5255 5622 52 88
Fax: +5255 5622 53 29
Email: pereda@unam.mx