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DOI: 10.1055/s-0031-1298201
© Georg Thieme Verlag KG Stuttgart · New York
Four New Cytotoxic Tetrahydrofuranoid Lignans from Sinopodophyllum emodi
Publikationsverlauf
received October 12, 2011
revised December 8, 2011
accepted January 3, 2012
Publikationsdatum:
26. Januar 2012 (online)
![](https://www.thieme-connect.de/media/plantamedica/201205/lookinside/thumbnails/10.1055-s-0031-1298201-1.jpg)
Abstract
Four new tetrahydrofuranoid lignans, (−)-tanegool-7′-methyl ether (1), (+)-7′-methoxylariciresinol (2), sinolignan C (3), and epipinoresinol-4,4′-di-O-β-D-glucopyranoside (4), were isolated from the roots and rhizomes of Sinopodophyllum emodi together with one known lignan (5). Their structures and stereochemistry were elucidated on the basis of spectroscopic and mass spectrometric evidence. The isolation of compounds 1–5 represents the first report of tetrahydrofuran lignans from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated against HeLa and KB cell lines, and compound 1 showed the most potent cytotoxicity with IC50 values of 9.7 µM and 4.7 µM, respectively.
Key words
tetrahydrofuranoid lignans - Sinopodophyllum emodi - Berberidaceae - cytotoxic activities
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Prof. Dr. Hui-Ming Hua
Key Laboratory of Structure-Based Drug Design & Discovery
Ministry of Education
School of Traditional Chinese Materia Medica
Shenyang Pharmaceutical University
Box 49
Shenyang 110016
People's Republic of China
Telefon: +86 24 23 98 64 65
Fax: +86 24 23 98 64 65
eMail: huimhua@163.com
Prof. Dr. Hong Chen
Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard
Pharmacognosy Division
Medical College of Chinese People's Armed Police Force
No. 222, Chenglin Road
Tianjin 300162
People's Republic of China
Telefon: +86 22 60 57 81 93
Fax: +86 22 60 57 81 93
eMail: Chenhongtian06@yahoo.com.cn