Download PDF
Zeitschrift für Phytotherapie 2013; 34(1): 12-15
DOI: 10.1055/s-0032-1331480
Übersicht
Fettstoffwechselstörungen
© Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Phytotherapeutische Optionen bei Fettstoffwechselstörungen

Karin Kraft
Subject Editor:
Further Information

Publication History

Publication Date:
28 March 2013 (online)

    Permissions and Reprints

Zusammenfassung

Der Artikel gibt einen Überblick über bekannte Wirkprinzipien von pflanzlichen Drogen bei Hyperlipidämien und über die Situation hinsichtlich klinischer Studien. Ballaststoffhaltige Dogen, insbesondere Flohsamen, scheinen sich zumindest zur adjuvanten Therapie gut zu eignen. Studien mit Knoblauch zeigen inkonsistente Ergebnisse, für Artischockenblätter gibt es zu wenig Studien. Weitere Untersuchungen sind aufgrund der allgemein guten Verträglichkeit der bisher identifizierten pflanzlichen Drogen unbedingt zu empfehlen.

Summary

Phytotherapeutic options for hyperlipidemia

The article gives an overview of common pharmacological effects of herbal remedies for treating hyperlipidemia as well as the current state of clinical trials. Fibercontaining remedies, particularly psyllium, are identified to be suitable at least for adjuvant therapy. Studies on garlic show inconsistent results, and studies on artichoke leaves are still rare. The herbal remedies identified so far as promising in treating hyperlipidemia are well tolerated, therefore further studies should be conducted.

Schlüsselwörter

Fettstoffwechselstörungen - klinische Studien - Flohsamen - Ballaststoffe - Artischocke - Knoblauch

Key words

Hyperlipidemia - clinical trials - psyllium - fiber - artichoke - garlic
 

  • Literatur

  • 1 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002 106. 3143-3421
    PubMed
  • 2 Anderson JW, Allgood LD, Lawrence A et al. Cholesterol-lowering effects of psyllium Intake adjunctive to diet therapy in men and women with hypercholesterolemia: metaanalysis of 8 controlled trials. Am J Clin Nutr 2000; 71: 472-479
    PubMedSearch in Google Scholar
  • 3 Wei ZH, Wang H, Chen XY et al. Time- and dose-dependent effect of psyllium on serum lipids in mild-to-moderate hypercholesterolemia: a meta-analysis of controlled clinical trials. Eur J Clin Nutr 2009; 63: 821-827
    CrossrefPubMedSearch in Google Scholar
  • 4 Anderson JW, Davidson MH, Blonde L et al. Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am J Clin Nutr 2000; 71: 1433-1438
    PubMedSearch in Google Scholar
  • 5 Sartore G, Reitano R, Barison A et al. The effects of psyllium on lipoproteins in type II diabetic patients.. Eur J Clin Nutr 2009; 63: 1269-1271
    CrossrefPubMedSearch in Google Scholar
  • 6 Petchetti L, Frishman WH, Petrillo R, Raju K. Nutriceuticals in cardiovascular disease: psyllium. Cardiol Rev 2007; 15: 116-122
    CrossrefPubMedSearch in Google Scholar
  • 7 Talati R, Baker WL, Pabilonia MS et al. The effects of barley-derived soluble fiber on serum lipids. Ann Fam Med 2009; 7: 157-163
    CrossrefPubMedSearch in Google Scholar
  • 8 Fukumitsu S, Aida K, Shimizu H, Toyoda K Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutr Res 2010; 30: 441-446
    CrossrefPubMedSearch in Google Scholar
  • 9 Brouns F, Theuwissen E, Adam A et al. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women.. Eur J Clin Nutr 2012; 66: 591-599
    CrossrefPubMedSearch in Google Scholar
  • 10 Wider B, Pittler MH, Thompson-Coon J, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia.. Cochrane Database Syst Rev 2009; CD003335
    PubMedSearch in Google Scholar
  • 11 Sangeetha T, Darlin QuineS. Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury.. J Pharm Pharmacol 2006; 58: 617-623
    CrossrefPubMedSearch in Google Scholar
  • 12 Liu L, Yeh YY. S-alk(en)yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes.. J Nutr 2002; 132: 1129-1134
    PubMedSearch in Google Scholar
  • 13 Kumar RV, Banerji A, Kurup CK, Ramasarma T. The nature of inhibition of 3-hydroxy-3-methylglutaryl CoA reductase by garlic-derived diallyl disulfide.. Biochim Biophys Acta 1991; 1078: 219-225
    CrossrefPubMedSearch in Google Scholar
  • 14 Reinhart KM, Talati R, White CM, Coleman CI. The impact of garlic on lipid parameters: a systematic review and meta-analysis.. Nutr Res Rev 2009; 22: 39-48
    CrossrefPubMedSearch in Google Scholar
  • 15 Khoo YS, Aziz Z. Garlic supplementation and serum cholesterol: a meta-analysis. J Clin Pharm Ther 2009; 34: 133-145
    CrossrefPubMedSearch in Google Scholar
  • 16 Kianbakht S, Abasi B, Perham M et al. Anti-hyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial. Phytother Res 2011; 25: 1849-1853
    CrossrefPubMedSearch in Google Scholar
  • 17 Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N et al. Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Med Arh 2012; 66: 198-200
    CrossrefPubMedSearch in Google Scholar
  • 18 de Morais EC, Stefanuto A, Klein GA. et al. Consumption of yerba mate (Ilexparagua-riensis) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy. J Agric Food Chem 2009; 57: 8316-8324
    CrossrefPubMedSearch in Google Scholar