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DOI: 10.1055/s-0032-1333227
Effect of the Treatment with Alpha-Macroglobulin on the Development of Experimental Pancreatitis
Publication History
received 01 August 2012
accepted 11 December 2012
Publication Date:
17 January 2013 (online)
![](https://www.thieme-connect.de/media/drugres/201302/lookinside/thumbnails/10.1055-s-0032-1333227-1.jpg)
Abstract
Alpha-macroglobulins are proteinase inhibitors. Monofluorophosphate increases alpha-macroglobulin levels in plasma, inducing a higher survival rate and lower pancreatic damage in rats with pancreatitis. The aim of this study was to evaluate the effect of alpha-macroglobulin on the development of pancreatitis. Pancreatitis was surgically induced in Sprague-Dawley rats divided into groups of 16 rats each and subjected to the following intravenous treatments for 3 days: Controls: pancreatitis without treatment, Enriched plasma: pancreatitis+alpha-macroglobulin-enriched plasma, Normal plasma: pancreatitis+plasma with normal levels of alpha-macroglobulin, Saline Solution: pancreatitis+saline solution, Purified alpha-macroglobulin: pancreatitis+purified alpha-macroglobulin. After 14 days pancreatic damage was assessed using a score that measures: edema, fibrin, neutrophils, mononuclear leukocytes, necrosis, vascular congestion, thrombosis, hemorrhage and fibrosis. Pancreatic damage decreased and the percentage of animals with pancreatitis was lower in enriched-plasma and purified alpha-macroglobulin groups. We conclude that the intravenous administration of alpha-macroglobulins causes a reduction in the histological damage produced by pancreatitis.
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