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Synthesis 2014; 46(02): 189-194
DOI: 10.1055/s-0033-1338558
DOI: 10.1055/s-0033-1338558
paper
First Total Synthesis of (–)-Auranomide C and Its Derivatives
Further Information
Publication History
Received: 15 August 2013
Accepted after revision: 24 October 2013
Publication Date:
14 November 2013 (online)
Abstract
The first total synthesis of (–)-auranomide C has been achieved. The short synthetic strategy involves a reductive dehydrocyclization and the nucleophilic ring opening of a fused γ-lactam. The route allows for ease in synthesizing diverse derivatives in the side chain of the natural product.
Key words
auranomide - quinazolinobenzodiazepine - intramolecular cyclization - reductive dehydrocyclization - nucleophilic ring openingSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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