NIS-Mediated Oxidative Lactonization of 2-Arylbenzoic Acids for the Synthesis­ of Dibenzopyranones under Metal-Free Conditions

Peng Gao; Yunyang Wei

doi:10.1055/s-0033-1338568

Synthesis, Inhaltsverzeichnis

Synthesis 2014; 46(03): 343-347
DOI: 10.1055/s-0033-1338568

paper

NIS-Mediated Oxidative Lactonization of 2-Arylbenzoic Acids for the Synthesis of Dibenzopyranones under Metal-Free Conditions

Peng Gao

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. of China Fax: +86(25)84317078 eMail: ywei@mail.njust.edu.cn

,

Yunyang Wei*

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. of China Fax: +86(25)84317078 eMail: ywei@mail.njust.edu.cn

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Abstract

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Abstract

A series of dibenzopyranones were synthesized from 2-arylbenzoic acids by a radical oxidative cyclization procedure mediated by N-iodosuccinimide (NIS). The methodology is distinguished by its practicality in terms of its wide substrate scope, good functional group tolerance, and mild reaction conditions without the use of transition metals.

Key words

lactones - oxidation - carboxylic acids - cyclization - radical reaction

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Referenzen

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Supporting Information

NIS-Mediated Oxidative Lactonization of 2-Arylbenzoic Acids for the Synthesis­ of Dibenzopyranones under Metal-Free Conditions

NIS-Mediated Oxidative Lactonization of 2-Arylbenzoic Acids for the Synthesis of Dibenzopyranones under Metal-Free Conditions