Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules

Abstract

A series of twelve fluorescently labeled amino acids were designed by assembling different coumarin, fluorescein, or nitrobenzo­furazan fluorophores with N-protected lysine or 2-aminopropionic acid. The synthesized amino acids were evaluated with regard to their spectroscopic properties. The easy introduction of the amino acids into peptides and peptidomimetics was exemplarily shown for one coumarin-labeled­ amino acid.

Key words

amino acids - coumarins - fluorescence - guanidines - peptido­mimetics

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