Subscribe to RSS
DOI: 10.1055/s-0036-1592168
Critical Care Management after Cardiac Arrest
Publication History
Publication Date:
01 December 2016 (online)

Abstract
Sudden cardiac arrest is a devastating event with high mortality and substantial morbidity among survivors. Early recognition and intervention to restore circulation is the primary goal; once that is achieved, the path toward a meaningful recovery starts. Initial in-hospital care is focused on emergency cardiac care, but soon there is a change to a more brain-oriented critical care including targeted temperature management, brain monitoring, sedation, and repeated neurologic assessments. In patients who show early signs of awakening from coma once sedation has been stopped, the prognosis is generally good. In patients with early seizures and prolonged coma after sedation has been weaned, the prognosis is often poor. A structured model for neuroprognostication using several prognostication tools such as imaging, neurophysiology, biomarkers, and above all repeated clinical investigations is fundamental for the ability to properly assess the comatose cardiac arrest patient and to enable accurate and trustworthy decisions on level of care. The authors present a model for critical care management after cardiac arrest and a neuroprognostication algorithm, both in use at their institution.
-
References
- 1 Berdowski J, Berg RA, Tijssen JG, Koster RW. Global incidences of out-of-hospital cardiac arrest and survival rates: systematic review of 67 prospective studies. Resuscitation 2010; 81 (11) 1479-1487
- 2 Kitamura T, Iwami T, Kawamura T , et al; Japanese Circulation Society Resuscitation Science Study Group. Nationwide improvements in survival from out-of-hospital cardiac arrest in Japan. Circulation 2012; 126 (24) 2834-2843
- 3 Sasson C, Rogers MA, Dahl J, Kellermann AL. Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 2010; 3 (1) 63-81
- 4 Lindner TW, Søreide E, Nilsen OB, Torunn MW, Lossius HM. Good outcome in every fourth resuscitation attempt is achievable—an Utstein template report from the Stavanger region. Resuscitation 2011; 82 (12) 1508-1513
- 5 Hasselqvist-Ax I, Riva G, Herlitz J , et al. Early cardiopulmonary resuscitation in out-of-hospital cardiac arrest. N Engl J Med 2015; 372 (24) 2307-2315
- 6 Wissenberg M, Lippert FK, Folke F , et al. Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA 2013; 310 (13) 1377-1384
- 7 Nielsen N, Hovdenes J, Nilsson F , et al; Hypothermia Network. Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest. Acta Anaesthesiol Scand 2009; 53 (7) 926-934
- 8 Sunde K, Pytte M, Jacobsen D , et al. Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation 2007; 73 (1) 29-39
- 9 Deakin CD, Fothergill R, Moore F, Watson L, Whitbread M. Level of consciousness on admission to a Heart Attack Centre is a predictor of survival from out-of-hospital cardiac arrest. Resuscitation 2014; 85 (7) 905-909
- 10 Maupain C, Bougouin W, Lamhaut L , et al. The CAHP (Cardiac Arrest Hospital Prognosis) score: a tool for risk stratification after out-of-hospital cardiac arrest. Eur Heart J 2015;
- 11 Dankiewicz J, Nielsen N, Annborn M , et al. Survival in patients without acute ST elevation after cardiac arrest and association with early coronary angiography: a post hoc analysis from the TTM trial. Intensive Care Med 2015; 41 (5) 856-864
- 12 Kolh P, Windecker S. ESC/EACTS myocardial revascularization guidelines 2014. Eur Heart J 2014; 35 (46) 3235-3236
- 13 Cariou A, Nolan JP, Sunde K. Ten strategies to increase survival of cardiac arrest patients. Intensive Care Med 2015; 41 (10) 1820-1823
- 14 Adrie C, Adib-Conquy M, Laurent I , et al. Successful cardiopulmonary resuscitation after cardiac arrest as a “sepsis-like” syndrome. Circulation 2002; 106 (5) 562-568
- 15 Monsieurs KG, Nolan JP, Bossaert LL , et al; ERC Guidelines 2015 Writing Group. European Resuscitation Council Guidelines for Resuscitation 2015: Section 1. Executive summary. Resuscitation 2015; 95: 1-80
- 16 Wieloch T, Harris RJ, Siesjö BK. Brain metabolism and ischemia: mechanism of cell damage and principles of protection. J Cereb Blood Flow Metab 1982; 2 (Suppl. 01) S5-S9
- 17 Dragancea I, Rundgren M, Englund E, Friberg H, Cronberg T. The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest. Resuscitation 2013; 84 (3) 337-342
- 18 Sandroni C, Cariou A, Cavallaro F , et al. Prognostication in comatose survivors of cardiac arrest: an advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine. Resuscitation 2014; 85 (12) 1779-1789
- 19 Nolan JP, Soar J, Cariou A , et al. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015: Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation 2015; 95: 202-222
- 20 Nielsen N, Wetterslev J, Cronberg T , et al; TTM Trial Investigators. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013; 369 (23) 2197-2206
- 21 Deye N, Cariou A, Girardie P , et al; Clinical and Economical Impact of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA) Study Group. Endovascular Versus External Targeted Temperature Management for Patients With Out-of-Hospital Cardiac Arrest: a randomized, controlled study. Circulation 2015; 132 (3) 182-193
- 22 Choi HA, Ko SB, Presciutti M , et al. Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol. Neurocrit Care 2011; 14 (3) 389-394
- 23 Rundgren M, Westhall E, Cronberg T, Rosén I, Friberg H. Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients. Crit Care Med 2010; 38 (9) 1838-1844
- 24 Claassen J, Taccone FS, Horn P, Holtkamp M, Stocchetti N, Oddo M ; Neurointensive Care Section of the European Society of Intensive Care Medicine. Recommendations on the use of EEG monitoring in critically ill patients: consensus statement from the neurointensive care section of the ESICM. Intensive Care Med 2013; 39 (8) 1337-1351
- 25 Oh SH, Park KN, Shon YM , et al. Continuous amplitude-integrated electroencephalographic monitoring is a useful prognostic tool for hypothermia-treated cardiac arrest patients. Circulation 2015; 132 (12) 1094-1103
- 26 Bellomo R, Bailey M, Eastwood GM , et al; Study of Oxygen in Critical Care (SOCC) Group. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care 2011; 15 (2) R90
- 27 Kilgannon JH, Jones AE, Parrillo JE , et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation 2011; 123 (23) 2717-2722
- 28 Wang CH, Chang WT, Huang CH , et al. The effect of hyperoxia on survival following adult cardiac arrest: a systematic review and meta-analysis of observational studies. Resuscitation 2014; 85 (9) 1142-1148
- 29 Menon DK, Coles JP, Gupta AK , et al. Diffusion limited oxygen delivery following head injury. Crit Care Med 2004; 32 (6) 1384-1390
- 30 Falkenbach P, Kämäräinen A, Mäkelä A , et al. Incidence of iatrogenic dyscarbia during mild therapeutic hypothermia after successful resuscitation from out-of-hospital cardiac arrest. Resuscitation 2009; 80 (9) 990-993
- 31 Kim SH, Choi SP, Park KN , et al; Korean Hypothermia Network Investigators. Association of blood glucose at admission with outcomes in patients treated with therapeutic hypothermia after cardiac arrest. Am J Emerg Med 2014; 32 (8) 900-904
- 32 Daviaud F, Dumas F, Demars N , et al. Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era. Intensive Care Med 2014; 40 (6) 855-862
- 33 Oksanen T, Skrifvars MB, Varpula T , et al. Strict versus moderate glucose control after resuscitation from ventricular fibrillation. Intensive Care Med 2007; 33 (12) 2093-2100
- 34 Cueni-Villoz N, Devigili A, Delodder F , et al. Increased blood glucose variability during therapeutic hypothermia and outcome after cardiac arrest. Crit Care Med 2011; 39 (10) 2225-2231
- 35 Lee BK, Lee HY, Jeung KW, Jung YH, Lee GS, You Y. Association of blood glucose variability with outcomes in comatose cardiac arrest survivors treated with therapeutic hypothermia. Am J Emerg Med 2013; 31 (3) 566-572
- 36 Kilgannon JH, Roberts BW, Jones AE , et al. Arterial blood pressure and neurologic outcome after resuscitation from cardiac arrest. Crit Care Med 2014; 42 (9) 2083-2091
- 37 Bro-Jeppesen J, Annborn M, Hassager C , et al; TTM Investigators. Hemodynamics and vasopressor support during targeted temperature management at 33°C versus 36°C after out-of-hospital cardiac arrest: a post hoc study of the target temperature management trial. Crit Care Med 2015; 43 (2) 318-327
- 38 Bjelland TW, Dale O, Kaisen K , et al. Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial. Intensive Care Med 2012; 38 (6) 959-967
- 39 Chamorro C, Borrallo JM, Romera MA, Silva JA, Balandín B. Anesthesia and analgesia protocol during therapeutic hypothermia after cardiac arrest: a systematic review. Anesth Analg 2010; 110 (5) 1328-1335
- 40 Benbadis SR, Chen S, Melo M. What's shaking in the ICU? The differential diagnosis of seizures in the intensive care setting. Epilepsia 2010; 51 (11) 2338-2340
- 41 Seder DB, Sunde K, Rubertsson S , et al; International Cardiac Arrest Registry. Neurologic outcomes and postresuscitation care of patients with myoclonus following cardiac arrest. Crit Care Med 2015; 43 (5) 965-972
- 42 Snyder BD, Hauser WA, Loewenson RB, Leppik IE, Ramirez-Lassepas M, Gumnit RJ. Neurologic prognosis after cardiopulmonary arrest: III. Seizure activity. Neurology 1980; 30 (12) 1292-1297
- 43 Bouwes A, van Poppelen D, Koelman JH , et al. Acute posthypoxic myoclonus after cardiopulmonary resuscitation. BMC Neurol 2012; 12: 63
- 44 Lucas JM, Cocchi MN, Salciccioli J , et al. Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonus. Resuscitation 2012; 83 (2) 265-269
- 45 Werhahn KJ, Brown P, Thompson PD, Marsden CD. The clinical features and prognosis of chronic posthypoxic myoclonus. Mov Disord 1997; 12 (2) 216-220
- 46 Hirsch LJ, LaRoche SM, Gaspard N , et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2012 version. J Clin Neurophysiol 2013; 30 (1) 1-27
- 47 Dragancea I, Backman S, Westhall E, Rundgren M, Friberg H, Cronberg T. Outcome following postanoxic status epilepticus in patients with targeted temperature management after cardiac arrest. Epilepsy Behav 2015; 49: 173-177
- 48 Westhall E, Rossetti AO, van Rootselaar AF , et al; TTM-trial investigators. Standardized EEG interpretation accurately predicts prognosis after cardiac arrest. Neurology 2016; 86 (16) 1482-1490
- 49 Che D, Li L, Kopil CM, Liu Z, Guo W, Neumar RW. Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest. Crit Care Med 2011; 39 (6) 1423-1430
- 50 Coimbra C, Wieloch T. Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia. Acta Neuropathol 1994; 87 (4) 325-331
- 51 Colbourne F, Li H, Buchan AM. Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999; 19 (7) 742-749
- 52 Hickey RW, Ferimer H, Alexander HL , et al. Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats. Crit Care Med 2000; 28 (10) 3511-3516
- 53 Marion DW, Leonov Y, Ginsberg M , et al. Resuscitative hypothermia. Crit Care Med 1996; 24 (2, Suppl): S81-S89
- 54 Perel P, Roberts I, Sena E , et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 2007; 334 (7586) 197
- 55 Bernard SA, Gray TW, Buist MD , et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346 (8) 557-563
- 56 Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346 (8) 549-556
- 57 Deakin CD, Morrison LJ, Morley PT , et al; Advanced Life Support Chapter Collaborators. Part 8: Advanced Life Support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation 2010; 81 (Suppl. 01) e93-e174
- 58 Nolan JP, Morley PT, Vanden Hoek TL , et al; International Liaison Committee on Resuscitation. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003; 108 (1) 118-121
- 59 Arrich J, Holzer M, Havel C, Müllner M, Herkner H. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2012; 9 (9) CD004128
- 60 Biber B, Waldenström A. [New data on hypothermia. Now we have to keep cool!]. Lakartidningen 2004; 101 (6) 438-439
- 61 Fisher GC. Hypothermia after cardiac arrest: feasible but is it therapeutic?. Anaesthesia 2008; 63 (8) 885-886 , author reply 886
- 62 Nielsen N, Friberg H, Gluud C, Herlitz J, Wetterslev J. Hypothermia after cardiac arrest should be further evaluated—a systematic review of randomised trials with meta-analysis and trial sequential analysis. Int J Cardiol 2011; 151 (3) 333-341
- 63 Cronberg T, Lilja G, Horn J , et al; TTM Trial Investigators. Neurologic Function and Health-Related Quality of Life in Patients Following Targeted Temperature Management at 33°C vs 36°C After Out-of-Hospital Cardiac Arrest: a randomized clinical trial. JAMA Neurol 2015; 72 (6) 634-641
- 64 Lilja G, Nielsen N, Friberg H , et al. Cognitive function in survivors of out-of-hospital cardiac arrest after target temperature management at 33°C versus 36°C. Circulation 2015; 131 (15) 1340-1349
- 65 Nielsen N, Friberg H. Temperature management after cardiac arrest. Curr Opin Crit Care 2015; 21 (3) 202-208
- 66 Moulaert VR, Verbunt JA, van Heugten CM, Wade DT. Cognitive impairments in survivors of out-of-hospital cardiac arrest: a systematic review. Resuscitation 2009; 80 (3) 297-305
- 67 Sandroni C, Cariou A, Cavallaro F , et al. Prognostication in comatose survivors of cardiac arrest: an advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine. Intensive Care Med 2014; 40 (12) 1816-1831
- 68 Al Thenayan E, Savard M, Sharpe M, Norton L, Young B. Predictors of poor neurologic outcome after induced mild hypothermia following cardiac arrest. Neurology 2008; 71 (19) 1535-1537
- 69 Steffen IG, Hasper D, Ploner CJ , et al. Mild therapeutic hypothermia alters neuron specific enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients. Crit Care 2010; 14 (2) R69
- 70 Samaniego EA, Persoon S, Wijman CA. Prognosis after cardiac arrest and hypothermia: a new paradigm. Curr Neurol Neurosci Rep 2011; 11 (1) 111-119
- 71 Dragancea I, Horn J, Kuiper M , et al; TTM Trial Investigators. Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: results from a randomised controlled clinical trial. Resuscitation 2015; 93: 164-170
- 72 Stammet P, Collignon O, Hassager C , et al; TTM-Trial Investigators. Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33°C and 36°C. J Am Coll Cardiol 2015; 65 (19) 2104-2114
- 73 Gold B, Puertas L, Davis SP , et al. Awakening after cardiac arrest and post resuscitation hypothermia: are we pulling the plug too early?. Resuscitation 2014; 85 (2) 211-214
- 74 Cronberg T, Westhall E, Friberg H. Is continuous EEG-monitoring value for money for cardiac arrest patients in the intensive care unit?. Resuscitation 2014; 85 (6) 716-717
- 75 Suys T, Bouzat P, Marques-Vidal P , et al. Automated quantitative pupillometry for the prognostication of coma after cardiac arrest. Neurocrit Care 2014; 21 (2) 300-308