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CC BY-ND-NC 4.0 · Synthesis 2019; 51(05): 1049-1062
DOI: 10.1055/s-0037-1611649
DOI: 10.1055/s-0037-1611649
short review
Transition-Metal-Catalyzed Alkenyl sp2 C–H Activation: A Short Account
We are thankful to Nanyang Technological University, Singapore Ministry of Education Academic Research Fund [Tier 1: MOE2015-T1-001-070 (RG5/15), MOE2014-T1-001-102 (RG9/14) and MOE2018-T1-001-110 (RG12/18)], Nanjing Tech University, and the Singapore National Research Foundation (NRF2015NRF-POC001-024) for generous financial support. We gratefully acknowledge the funding support of the State Key Program of the National Natural Science Foundation of China (21432009), the National Natural Science Foundation of China (21372210, 21672198), the State Key Laboratory of Elemento-organic Chemistry, Nankai University (201620) and the Collaborative Innovation Center of Chemistry for Energy Materials (2011-iChEM) for financial support.Further Information
Publication History
Received: 23 November 2018
Accepted: 14 December 2018
Publication Date:
23 January 2019 (online)
Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue
Abstract
Alkenes are ubiquitous in Nature and their functionalization continues to attract attention from the scientific community. On the other hand, activation of alkenyl sp2 C–H bonds is challenging due to their chemical properties. In this short account, we elucidate, discuss and describe the utilization of transition-metal catalysts in alkene activation and provide useful strategies to synthesize organic building blocks in an efficient and sustainable manner.
1 Introduction
2 Breakthrough
3 Controlling E/Z, Z/E Selectivity
3.1 Esters and Amides as Directing Groups
3.2 The Chelation versus Non-Chelation Concept
4 Other Alkene Derivatives
5 Intramolecular C–H Activation
6 Conclusion and Future Projects
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For selected very recent reviews on transition-metal-catalyzed C–H activation, see:
For selected reviews on trifluoromethylations, see:
Selected reviews and examples of metal-catalyzed cross-couplings of enol phosphates:
For recent reviews, see: