The Effect of Some Platelet Aggregating and Potential Thrombosis-Promoting Substances on the Development of Experimental Arterial Thrombosis

J Hladovec

doi:10.1055/s-0038-1647760

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(01): 196-200
DOI: 10.1055/s-0038-1647760

Original Article

Schattauer GmbH

The Effect of Some Platelet Aggregating and Potential Thrombosis-Promoting Substances on the Development of Experimental Arterial Thrombosis

J Hladovec

¹Research Centre of Cardiovascular Diseases (Head: L. Hejhal, M. D., DrSc), Institute of Clinical and Experimental Medicine (Director: P. Mâlek, M. D., DrSc), Prague 4 - Krč (CSSR)

› Author Affiliations

Abstract

Summary

A series of platelet aggregating or potentially thrombosis-promoting agents was administered intravenously 1 minute before the electric provocation of thrombosis in the carotid artery of the rat. Adenosine diphosphate, adrenaline, thrombin, ellagic acid, tannin, ε-aminocaproic acid and Trasylol were ineffective in shortening the time of thrombosis. On the contrary, most of these drugs showed some antithrombotic effect. Only 5-hydroxytryptamine definitely potentiated the process of thrombosis.

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References

References
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