Platelet Monoamine Oxidase and Epinephrine-Induced Platelet Aggregation

Ennio C Rossi; Gerlinde Louis; Martha Bieber; E Albert Zeller

doi:10.1055/s-0038-1648632

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1978; 40(01): 037-042
DOI: 10.1055/s-0038-1648632

Original Article

Schattauer GmbH Stuttgart

Platelet Monoamine Oxidase and Epinephrine-Induced Platelet Aggregation

Authors

Ennio C Rossi

The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
Gerlinde Louis

The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
Martha Bieber

The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
E Albert Zeller

The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.

Abstract

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Summary

Platelet MAO activity and the aggregation response to epinephrine, ADP, and collagen were measured in normal subjects. There was a direct correlation between the amount of platelet MAO activity and the per cent aggregation induced by 1 and 2 μM epinephrine. There were lesser correlations between platelet MAO and ADP or collagen-induced aggregation. These findings suggest that platelet MAO may play a role in determining the response of human platelets to epinephrine.

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Referenzen

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