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Thromb Haemost 1987; 57(03): 283-285
DOI: 10.1055/s-0038-1651117
Original Article
Schattauer GmbH Stuttgart

The Antithrombogenic In Vivo Effects of Calcium Channel Blockers in Experimental Thrombosis in Mice

M P Ortega
*   The Departamento de Investigación, Alter, S. A., Mateo Inurria, Madrid, Spain
,
C Sunkel
*   The Departamento de Investigación, Alter, S. A., Mateo Inurria, Madrid, Spain
,
J G Priego
*   The Departamento de Investigación, Alter, S. A., Mateo Inurria, Madrid, Spain
,
P R Statkow
**   The Cermol, S. A., Geneva, Switzerland
› Author Affiliations
Further Information

Publication History

Received 17 June 1986

Accepted after revision 17 February 1987

Publication Date:
06 July 2018 (online)

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Summary

A new model of thrombotic challenge, well suited for screening agents and which acts primarily against platelet thromboembolism, has been used to test the in vivo anti-platelet effects of four calcium channel blockers (CCB). An i. v. injection of a mixture of collagen plus epinephrine (15 μg and 1.8 μg/mouse, respectively) was given to male mice. 94% control mice died or remained paralyzed for more than 15 minutes. The dihydropyridine agents, CRE-223 and Nifedipine, were highly protective against experimental thrombosis, whereas Verapamil had a weaker and much shorter effect and, on the other hand, Diltiazem had no protective effect over a range of doses. The activity on both dihydropyridines lasted for seven hours or even longer.

Keywords

Calcium channel blockers - Antithrombotic agents - Thrombosis model - Dihydropyridines - Verapamil - Diltiazem
 

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