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Thromb Haemost 1968; 19(03/04): 383-388
DOI: 10.1055/s-0038-1651216
Originalarbeiten – Original Articles – Travaux Originaux
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Metabolic Studies of Vitamin K1-14C and Menadione-14C in the Normal and Hepatectomized Rats[*]

R Losito Ph. D.
1   Mayo Clinic and Mayo Foundation: Section of Biochemistry
,
C. A Owen Jr. M. D.
1   Mayo Clinic and Mayo Foundation: Section of Biochemistry
,
E. V Flock Ph. D.
1   Mayo Clinic and Mayo Foundation: Section of Biochemistry
,
Rochester, Minnesota › Author Affiliations
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Publication Date:
27 June 2018 (online)

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Summary

The metabolism of vitamin K1- 14C and menadione-14C (vitamin K3-14C) was studied in normal and hepateetomized rats. After the administration of menadione, about 70% of the 14C was excreted in the urine in 24 hrs in both types of rats. Two urinary metabolites were identified by enzymatic hydrolysis: one a glucuronide and the other a sulfate of reduced menadione. Thus, the liver is not necessary for the metabolism of menadione. In the vitamin K1 studies, the intact rats excreted only 10% of the 14C and the hepatectomized rats excreted less than 0.5%. The retention of vitamin K1 may explain its superiority over menadione as an antidote for overdosages of oral anticoagulants.

* This investigation was supported in part by Research Grants AM-3932 and HE-9863 from the National Institutes of Health, Public Health Service, and by a grant from the Medical Research Council of Canada.


 

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