Download PDF
Thromb Haemost 1997; 78(01): 083-087
DOI: 10.1055/s-0038-1657506
Integrin signalling and vascular function
Schattauer GmbH Stuttgart

Targeted Mutations in Integrins and their Ligands: Their Implications for Vascular Biology

Richard O Hynes
Howard Hughes Medical Instilute, Center for Cancer Research, Department of Biology, Massachusetts lnstitute of Technology, Cambridge, MA, USA
,
Bernhard L Bader
Howard Hughes Medical Instilute, Center for Cancer Research, Department of Biology, Massachusetts lnstitute of Technology, Cambridge, MA, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Hynes RO, and Lander AD. 1992; Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68: 303-322
    CrossrefPubMedGoogle Scholar
  • 2 Hynes RO. 1992; Integrins: versatility, modulation and signalling in cell adhesion. Cell 69: 11-25
    CrossrefPubMedGoogle Scholar
  • 3 Springer TA. 1994; Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314
    CrossrefPubMedGoogle Scholar
  • 4 McEver RP, Moore KL, and Cummings RD. 1995; Leukocyte trafficking mediated by selectin-carbohydrate interactions. J.Biol.Chem 270: 11025-11028
    PubMedGoogle Scholar
  • 5 Tedder TF. 1995; The selectins: vascular adhesion molecules. FASEB J. 9: 866-873
    CrossrefPubMedGoogle Scholar
  • 6 Hynes RO. 1996; Targeted mutations in cell adhesion genes: what have we learned from them? Dev. Biol 180: 402-412
    PubMedGoogle Scholar
  • 7 Fässler R, Georges-Labouesse E, Hirsch E. 1996; Genetic analyses of integrin function in mice. Curr.Opin Cell Biol 8: 641-646
    PubMedGoogle Scholar
  • 8 Piali L, Hammel R, Uherek C, Bachmann F, Gisler RH, Dunon D, Imohof BA. 1995; CD31/PECAM-1 is a ligand for αvβ3 integrin involved in adhesion of leukocytes to endothelium. J.Cell Biol 130: 451-460
    CrossrefPubMedGoogle Scholar
  • 9 Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, and Brenner MB. 1994; Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin. Nature 372: 190-193
    CrossrefPubMedGoogle Scholar
  • 10 Karecla PI, Bowden SJ, Green SJ, and Kilshaw PJ. 1995; Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin αM290β7 (αEβ7). Eur.J.Immunol 25: 852-856
    PubMedGoogle Scholar
  • 11 Shattil SJ. 1995; Function and regulation of the b3 integrins in hemostasis and vascular biology. Thromb.Haem 74: 149-155
    PubMedGoogle Scholar
  • 12 Ruoslahti E. 1996; RGD and other recognition sequences for integrins. Annu.Rev.Cell Dev.Biol 12: 697-715
    PubMedGoogle Scholar
  • 13 Anderson DC, and Springer TA. 1987; Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and pl50,95 glycoproteins. Ann.Rev.Medicine 38: 175-194
    PubMedGoogle Scholar
  • 14 Nieuwenhuis HK, Akkerman JW N, Houdijk WP M, and Sixma JJ. 1985; Human blood platelets showing no response to collagen fail to express surface glycoprotein la. Nature 318: 470-472
    CrossrefPubMedGoogle Scholar
  • 15 Sadler JE, Matsushita T, Dong Z, Tuley EA, and Westfield LA. 1995; Molecular mechanism and classification of von Willebrand disease. Throm.and Haem 74: 161-166
    PubMedGoogle Scholar
  • 16 George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, and Hynes RO. 1993; Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119: 1079-1091
    PubMedGoogle Scholar
  • 17 Georges-Labouesse EN, George EL, Rayburn H, and Hynes RO. 1996; Mesodermal development in murine embryos mutated in the fibronectin gene. Dev.Dyn 207: 145-156
    PubMedGoogle Scholar
  • 18 George EL, Baldwin S, and Hynes RO. Fibronectins are essential for heart and blood vessel morphogenesis, but are dispensible for initial specification of precursor cells, (submitted).
    PubMedGoogle Scholar
  • 19 Yang JT, Rayburn H, and Hynes RO. 1993; Embryonic mesodermal defects in α5-integrin-deficient mice. Development 119: 1093-1105
    CrossrefPubMedGoogle Scholar
  • 20 Yang JT, and Hynes RO. 1996; Fibronectin receptor functions in embryonic cells deficient in α5β1 integrin can be replaced by αv integrins. Mol.Biol.Cell 7: 1737-1748
    PubMedGoogle Scholar
  • 21 Varner JA, Brooks PC, and Cheresh DA. 1995; Review: The integrin αvβ3: angiogenesis and apoptosis. Cell Adh.Commun 3: 367-374
    PubMedGoogle Scholar
  • 22 Dameron KM, Volpert OV, Tainsky MA, Bouck N. 1994; Control of angiogenesis in fibroblasts by regulation of thrombospondin-1. Science 265: 1582-1585
    CrossrefPubMedGoogle Scholar
  • 23 Roberts DD. 1996; Regulation of tumor growth and metastasis by thrombospondin-1. FASEB.J 10: 1183-1191
    CrossrefPubMedGoogle Scholar
  • 24 Stellmach V, Volpert OV, Crawford SE, Lawler J, Hynes RO, and Bouck N. 1997; Tumor suppressor genes and angiogenesis: the role of TP53 in fibroblasts. Eur.J.Cancer 32A: 2394-2400
    PubMedGoogle Scholar
  • 25 Yang JT, Rayburn H, and Hynes RO. 1995; Cell adhesion events mediated by a4 integrins are essential in placental and cardiac development. Development 121: 549-560
    PubMedGoogle Scholar
  • 26 Kwee L, Baldwin S, Stewart CS, Buck C, and Labow MA. 1995; Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1 deficient mice. Development 121: 489-503
    PubMedGoogle Scholar
  • 27 Gurtner GC, Davis V, Li H, McCoy MJ, Sharp A, and Cybulsky MI. 1995; Targeted disruption of the murine VCAM-1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes and Dev 9: 01-14
    CrossrefPubMedGoogle Scholar
  • 28 Wagner N, Lvhler J, Kunkel EJ, Ley K, Leung E, Krissansen G, Rajewsky K, and Miller W. 1996; Essential role for β7 integrins in the formation of the gut associated lymphoid tissue. Nature 382: 366-370
    CrossrefPubMedGoogle Scholar
  • 29 Schön MP, Grusby MJ, Murphy EA, Adams CM, Donohue JP, Arya A, Agace WW, Brenner MB, and Parker CM. 1997 Integrin αE (CD103) mediates mucosal T cell localization and the generation of intestinal inflammation, (submitted).
    PubMedGoogle Scholar
  • 30 Arroyo AG, Yang JT, Rayburn H, and Hynes RO. 1996; Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell 85: 0997-1008
    CrossrefPubMedGoogle Scholar
  • 31 Hirsch E, Iglesias A, Potocnik AJ, Hartmann U, and Fässler R. 1996; Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins. Nature 380: 171-175
    CrossrefPubMedGoogle Scholar
  • 32 Wilson RW, Ballantyne CM, Smith SW, Montgomery C, Bradley A, O’Brien WE, and Beuadet AL. 1993; Gene targeting yields a CD18-mutant mouse for study of inflammation. J.Immunol 151: 1571-1578
    PubMedGoogle Scholar
  • 33 Sligh JE, Ballantyne Jr CM, Rich SS, Hawkins HK, Smith CW, Bradley A, and Beaudet AL. 1993; Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc.Natl.Acad.Sci.USA 90: 8529-8533
    CrossrefPubMedGoogle Scholar
  • 34 Xu H, Gonzalo JA, St PierreY, Williams IR, Kupper TS, Cotran RS, Springer TA, and Gutierrez-Ramos JC. 1994; Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J.Exp.Med 180: 095-109
    CrossrefPubMedGoogle Scholar
  • 35 King PD, Sandberg ET, Selvakumar A, Fang P, Beaudet AL, and Dupont B. 1995; Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing. J.Immunol 154: 6080-6093
    PubMedGoogle Scholar
  • 36 Schmits R, Kündig TM, Baker DM, Shumaker G, Simard JJ L, Duncan G, Wakeham A, Shahinian A, van der Heiden A, Bachjmann MF, Ohashi PS, Mak TW, and Hickstein DD. 1996; LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J.Exp.Med 183: 1415-1426
    CrossrefPubMedGoogle Scholar
  • 37 Shier P, Otulakowski G, Ngo K, Panakos J, Chourmouzis E, Christjansen L, Lau CY, and Fung-Leung WP. 1996; Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the (β2 integrin leukocyte function-associated antigen-1. J.Immunol 157: 5375-5386
    PubMedGoogle Scholar
  • 38 Coxon A, Rieu P, Barkalow FJ, Askari S, von Andrian UH, Arnaout MA, and Mayadas TN. 1996; A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5: 653-666
    CrossrefPubMedGoogle Scholar
  • 39 Hodivala-Dilke KM, McHugh K, Raybum H, Teitelbaum S, and Hynes RO. 1997 Generation of mice null for β3 integrins, unpublished data.
    PubMedGoogle Scholar
  • 40 Denis C, Rayburn H, Hynes RO, and Wagner DD. 1997. Generation of von Willebrand factor-deficient mice. Thromb.Haem. (in press).
    Google Scholar