J Knee Surg 2019; 32(07): 630-636
DOI: 10.1055/s-0038-1666868
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Preoperative Opioid Use in Knee Surgery Patients

Sean J. Meredith
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
,
Vidushan Nadarajah
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
2  Department of Orthopaedic Surgery and Rehabilitation Medicine, SUNY Downstate Medical Center, Brooklyn, New York
,
Julio J. Jauregui
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
,
Michael P. Smuda
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
,
Shaun H. Medina
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
,
Craig H. Bennett
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
,
Jonathan D. Packer
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
,
R. Frank Henn III
1  Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
› Author Affiliations
Funding This work was supported by a grant from The James Lawrence Kernan Hospital Endowment Fund, Incorporated.
Further Information

Publication History

25 April 2018

26 May 2018

Publication Date:
10 July 2018 (online)

Abstract

A cross-sectional analysis of data derived from patients undergoing knee surgery at a single institution was conducted. The objectives of the study were to determine the demographic, diagnostic, and psychologic factors associated with opioid use; and to determine the clinical correlates of opioid use. We hypothesized that preoperative opioid use would be associated with worse patient-reported outcome (PRO) measures. The sample consisted of 383 patients undergoing knee surgery. The patients were classified as either opioid or nonopioid users on the basis of medical record review. All participants completed a battery of clinical assessments, including the Patient-Reported Outcomes Measurement Information System computer adaptive testing in six domains: Physical Function, Pain Interference, Fatigue, Social Satisfaction, Anxiety, and Depression. Analyses were conducted to examine clinical variables as a function of opioid use. The results indicated that opioid use was associated with female gender, unemployment, smoking, higher American Society of Anesthesiologists scores, greater number of previous surgeries, depression or anxiety, and worse expectation of surgery (p < 0.05). Multivariable analysis found opioid use to be a significant independent predictor of multiple PRO measures in patients undergoing knee surgery. Potential explanations for these findings are presented, and clinical implications are discussed.

Ethical Approval

This study was approved by the Institutional Review Board (IRB) Committee at the University of Maryland, Baltimore (HP-00062261).