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Synthesis 2020; 52(22): 3415-3419
DOI: 10.1055/s-0040-1707346
DOI: 10.1055/s-0040-1707346
special topic
Copper-Catalyzed Asymmetric Hydroamination of Styrenes with piv ZPhos as Ligand
We thank Boehringer Ingelheim Pharmaceuticals for financial support.Further Information
Publication History
Received: 15 May 2020
Accepted after revision: 19 June 2020
Publication Date:
06 August 2020 (online)
Published as part of the Special Topic Synthesis in Industry
Abstract
A copper-catalyzed hydroamination of styrenes using piv ZPhos as ligand is reported. Enantioselectivities up to 94% are achieved under optimized conditions with aryl and heteroaryl styrenes. A variety of electrophilic O-benzoylhydroxylamines are well tolerated.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707346.
- Supporting Information
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