Nuklearmedizin 2020; 59(02): 184-185
DOI: 10.1055/s-0040-1708403
Wissenschaftliche Poster
Neurologie I
© Georg Thieme Verlag KG Stuttgart · New York

Value of FDG-PET as a Supporting Biomarker for Dementia with Lewy Bodies at Stages of Early Dopaminergic Loss

Autoren

  • L Beyer

    1   LMU München, Klinik und Poliklinik für Nuklearmedizin, München

  • M Huber

    1   LMU München, Klinik und Poliklinik für Nuklearmedizin, München

  • BS Rauchmann

    2   LMU München, Klinik für Psychiatrie und Psychotherapie, München

  • S Morbelli

    3   University of Genoa, Nuclear Medicine Unit, Genoa

  • R Bruffaerts

    4   University Hospitals Leuven, Department of Neurosciences, Leuven

  • R Vandenberghe

    4   University Hospitals Leuven, Department of Neurosciences, Leuven

  • N Nicastro

    5   Geneva University Hospitals, Department of Clinical Neurosciences, Geneva

  • AW Lemstra

    6   VU Medical Center Alzheimer Center, Amsterdam

  • S Garcia-Ptacek

    7   Karolinska Institutet, Medical Radiation Physics and Nuclear Medicine, Stockhol

  • MA Ochoa Figueroa

    8   Linköping University Hospital, Department of Clinical Physiology, Linköping

  • J Vöglein

    9   LMU München, Neurologische Klinik und Poliklinik, München

  • R Perneczky

    2   LMU München, Klinik für Psychiatrie und Psychotherapie, München

  • P Bartenstein

    1   LMU München, Klinik und Poliklinik für Nuklearmedizin, München

  • M Ewers

    10   LMU München, ISD, München

  • A Danek

    9   LMU München, Neurologische Klinik und Poliklinik, München

  • J Levin

    9   LMU München, Neurologische Klinik und Poliklinik, München

  • D Aarsland

    11   Stavanger University Hospital, Centre for Age-Related Medicine (SESAM), Stavanger

  • FM Nobili

    12   IRCCS Ospedale Policlinico San Martino, Genoa

  • A Rominger

    13   Inselspital University Hospital, Department of Nuclear Medicine, Bern

  • M Brendel

    1   LMU München, Klinik und Poliklinik für Nuklearmedizin, München
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
08. April 2020 (online)

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Ziel/Aim Metabolic network expression and dopamine availability were found to provide complementary information underlying the disease process in Parkinsonism. Disease-Related Patterns (DRP) in 18 F-fluorodesoxyglucose positron emission tomography (FDG-PET) were proposed to be used as an additional supporting biomarker in early diagnosis of Parkinson’s disease, multi-system atropy, progressive supranuclear palsy and corticobasal syndrome [1]. Therefore, we aimed to evaluate the diagnostic potential of a corresponding metabolic DRP in Dementia with Lewy bodies (DLB) as supporting biomarker in DLB.

Methodik/Methods We used the hitherto largest DLB cohort from the European consortium (E-DLB) with 84 patients having both dopamine transporter single photon emission computed tomography (DaT-SPECT) and metabolic (FDG-PET) imaging biomarkers available. The DLB related pattern (DLB-RP) was computed by voxel-wise comparison against healthy controls. Regional DLP-RP alterations were compared between DLB subjects with and without significant dopamine deficiency (2SD threshold).

Ergebnisse/Results The DLB-RP in FDG-PET was characterized by a relative hypometabolism in the parietal, occipital and, to a lesser extent, frontal and temporal cortices and a relative hypermetabolism in the basal ganglia, parts of the limbic system, the motor cortices and the cerebellum. Subjects without dopamine deficiency already showed a significant parietal hypometabolism and a significant hypermetabolismus in the motor cortex and cerebellum compared to healthy controls, but occipital hypometabolism and limbic hypermetabolism was only present with concurrent dopamine deficiency.

Schlussfolgerungen/Conclusions Patients with clinical DLB and normal DaT-SPECT already express parts of a metabolic DLB-RP in FDG-PET when compared to healthy controls. Detection of metabolic alterations at early stages of dopaminergic loss could serve as a supporting biomarker for timely diagnosis of DLB.

 

  • Literatur/References

  • 1 Ko J.H., Lee C.S., Eidelberg D. , Metabolic network expression in parkinsonism: Clinical and dopaminergic correlations. J Cereb Blood Flow Metab, 2017; . 37 (2): p. 683-693.
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