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CC BY 4.0 · Glob Med Genet 2020; 07(02): 041-046
DOI: 10.1055/s-0040-1715568
Original Article

The Role of PON1 Variants in Disease Susceptibility in a Turkish Population

Mahmoud Abudayyak 
1   Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
,
Tuğçe Boran 
1   Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
,
Rumeysa Tukel
1   Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
,
Ezgi Oztas 
1   Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
,
Gül Özhan 
1   Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
› Institutsangaben Funding This work was funded by the Research Fund of Istanbul University (Project No. TLO- 2018–27696).
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Abstract

Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed.

Keywords

paraoxonase-1 - hypothyroidism - pancreatitis


Publikationsverlauf

Artikel online veröffentlicht:
31. August 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Stuttgart · New York

 

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