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Exp Clin Endocrinol Diabetes 2017; 125(05): 335-341
DOI: 10.1055/s-0042-105279
Article
© Georg Thieme Verlag KG Stuttgart · New York

Impact of the Ile105Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population

E. O. Chielle
1   Center for Health Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil
3   Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil
,
A. Trott
3   Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil
,
B. da Silva Rosa
3   Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil
,
J. N. Casarin
3   Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil
,
P. C. Fortuna
3   Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil
,
I. B. M. da Cruz
2   Center of Natural and Exact Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil
,
M. B. Moretto
1   Center for Health Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil
,
R. N. Moresco
1   Center for Health Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil
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Publikationsverlauf

received 26. September 2015
first decision 26. Februar 2016

accepted 17. März 2016

Publikationsdatum:
22. September 2016 (online)

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Abstract

The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile105Val gene polymorphism of the study participants. Also, biochemical analysis and hormone assays were carried out. A positive association between GSTP1 polymorphism and obesity was observed on subjects carrying at least one G allele (AG and GG). GG genotype was found only in the obese group. The G allele carriers presented 2.4 times higher chance of obesity when compared to those with the AA genotype. These results were independent of sex and age. We suggest that despite a study in population regional (south of Brazil), the GSTP1 gene polymorphism may play a significant role in the increase of susceptibility of obesity and contribute to identify the cardiovascular risk in young adults.

Key words

obesity - glutathione - polymorphism - biomarkers - cardiometabolic
 

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