Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial

Neda Roshanravan; Reza Mahdavi; Effat Alizadeh; Mohammad Asghari Jafarabadi; Mehdi Hedayati; Abed Ghavami; Shahriar Alipour; Naimeh Mesri Alamdari; Meisam Barati; Alireza Ostadrahimi

doi:10.1055/s-0043-119089

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2017; 49(11): 886-891
DOI: 10.1055/s-0043-119089

Endocrine Care

Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial

Neda Roshanravan

¹Nutrition Research Center, Students Research Committee, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran

,

Reza Mahdavi

²Nutrition Research Center, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran

,

Effat Alizadeh

³Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Science, Tabriz, Iran

,

Mohammad Asghari Jafarabadi

⁴Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

⁵Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran

,

Mehdi Hedayati

⁶Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Abed Ghavami

²Nutrition Research Center, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran

,

Shahriar Alipour

⁷Department of Molecular Medicine, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

Naimeh Mesri Alamdari

⁸Student Research Committee, School of Health, Iran University of Medical Science, Tehran, Iran

,

Meisam Barati

²Nutrition Research Center, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran

,

Alireza Ostadrahimi

²Nutrition Research Center, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran

› Author Affiliations

Abstract

Studies on humans with diabetes mellitus showed that the crosstalk between the intestinal microbiota and the host has a key role in controlling the disease. The aim of this study was to evaluate the effects of sodium butyrate and high performance inulin supplementation simultaneously or singly on glycemic status, lipid profile, and glucagon-like peptide 1 level in adults with type 2 diabetes mellitus. Sixty patients were recruited for the study. The participants were randomly allocated, using randomized block procedure, to one of the four treatment groups (A, B, C, or D). Group A received sodium butyrate capsules, group B received inulin supplement powder, group C was exposed to the concomitant use of inulin and sodium butyrate, and group D consumed placebo for 45 consecutive days. Markers of glycemia, lipid profile, and glucagon-like peptide 1 were measured pre- and post-intervention. Dietary supplementation in groups A, B, and C significantly reduced diastolic blood pressure in comparison with the placebo group (p<0.05). Also, intra-group statistical analysis showed that only treatment with sodium butyrate + inulin (group C) significantly reduced fasting blood sugar (p=0.049) and waist to hip ratio (p=0.020). Waist circumference in groups B and C reduced significantly after the intervention (p=0.007 and p=0.011; respectively). The post hoc Tukey tests showed significant increase in glucagon-like peptide 1 concentration in groups A and C in comparison with group D (p<0.05). The results suggest that inulin supplementation may be useful to diabetic patients and these effects could be increased with butyrate supplement.

Key words

high performance inulin - sodium butyrate - glucagon-like peptide 1 - diabetes mellitus - dietary intake - lipid profile

Full Text

References

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Supplementary Material

Supplementary Material