Bupivacaine Versus Liposomal Bupivacaine For Pain Control

Abstract

Local infiltrations and regional blocks have been some of the effective ways employed to manage and control post-operative pain. One of the limitations of administration of local anesthesia drugs in post-operative conditions is its inability to act for a longer period of time. Multi-vesicular liposomes made up of bupivacaine have been progressively used for their increased duration of action. Compared to bupivacaine HCL, local infiltration of liposomal bupivacaine have shown to have a significantly increase the duration and delay in peak plasma concentration. In this article, we attempt to compare liposomal bupivacaine and bupivacaine based on available clinical literatures. Liposomal bupivacaine has been demonstrated to have promising implications in post- operative pain control resulting in increased patient satisfaction; reduced hospital admission and opioid induced adverse events. Clinical studies have identified liposomal bupivacaine to be effective in delivering increased post-operative pain control. The purpose of this review is to give a comprehensive comparison between bupivacaine liposomal and conventional bupivacaine based on reported clinical trials.

Key words

bupivacaine - bupivacaine liposomal - formulary - pharmacoeconomics

• References

• 1 Bangham AD, Hill MW, Miller NGA. Preparation and use of liposomes as models of biological membranes. In: Methods Membr. Biol 1974; 1-68
• 2 Terrien BD, Espinoza D, Stehman CC. et al. Thoracic epidural catheter for postoperative pain control following an ineffective transversus abdominis plane block using liposome bupivacaine. J Pain Res 2017; 10: 191
• 3 Etheridge ML, Campbell SA, Erdman AG. et al. The big picture on nanomedicine: The state of investigational and approved nanomedicine products. Nanomedicine Nanotechnology, Biol Med 2013; 9: 1-14
• 4 Daraee H, Etemadi A, Kouhi M. et al. Application of liposomes in medicine and drug delivery. Artif cells, nanomedicine, Biotechnol 2016; 44: 381-391
• 5 Bitounis D, Fanciullino R, Iliadis A. et al. Optimizing druggability through liposomal formulations: New approaches to an old concept. ISRN Pharm 2012; 2012: 738432
• 6 Daraee H, Eatemadi A, Abbasi E. et al. Application of gold nanoparticles in biomedical and drug delivery. Artif cells, nanomedicine, Biotechnol 2016; 44: 410-422
• 7 Mantripragada S. A lipid based depot (DepoFoam?? technology) for sustained release drug delivery. Prog Lipid Res 2002; 41: 392-406
• 8 Richard BM, Ott LR, Haan D. et al. The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs. Expert Opin Investig Drugs 2011; 20: 1327-1341
• 9 Richard BM, Rickert DE, Newton PE. et al. Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by repeated subcutaneous injection in rabbits and dogs: Species comparison. J Drug Deliv 2011; 2011: 467429
• 10 Beiranvand S, Eatemadi A, Karimi A. New updates pertaining to drug delivery of local anesthetics in particular bupivacaine using lipid nanoparticles. Nanoscale Res Lett 2016; 11: 1-10
• 11 Chahar P, Cummings KC. Liposomal bupivacaine: A review of a new bupivacaine formulation. J Pain Res 2012; 5: 257-264
• 12 Gorfine SR, Onel E, Patou G. et al. Bupivacaine extended-release liposome injection for prolonged postsurgical analgesia in patients undergoing hemorrhoidectomy: A multicenter, randomized, double-blind, placebo-controlled trial. Dis Colon Rectum 2011; 54: 1552-1559
• 13 Beiranvand S, Karimi A. Effect of encapsulated artemisia aucheri. L Magnetic Nanogel Extract on Shoulder Block in Rat. Drug Res 2017 (Stuttg)
• 14 Nadri S, Mahmoudvand H, Moradkhani MR. Magnesium sulfate mediate morphine administration reduction in varicocelectomy surgery. J Investig Surg 2017; 1-5
• 15 Smoot JD, Bergese SD, Onel E. et al. The efficacy and safety of depofoam bupivacaine in patients undergoing bilateral, cosmetic, submuscular augmentation mammaplasty: A randomized, double-blind, active-control study. Aesthetic Surg J 2012; 32: 69-76
• 16 Vahabi S, Beiranvand S. Effect of Local Ropivacaine on Hemodynamic Responses in Craniotomy Patients. J Investig Surg 2017; 1-5
• 17 Golf M, Daniels SE, Onel E. A phase 3, randomized, placebo-controlled trial of depofoam?? bupivacaine (extended-release bupivacaine local analgesic) in bunionectomy. Adv Ther 2011; 28: 776-788
• 18 SM C. Extended pain relief trial utilizing infiltration of Exparel((R)), a long- acting multivesicular liposome formulation of bupivacaine: A Phase IV health economic trial in adult patients undergoing open colectomy. J Pain Res 2012; 5: 567-572
• 19 Vahabi S, Eatemadi A. Nanoliposome encapsulated anesthetics for local anesthesia application. Biomed Pharmacother 2017; 86: 1-7
• 20 Moradkhani MR, Karimi A, Negahdari B. Nanotechnology application for pain therapy. Artif Cells, Nanomedicine, Biotechnol 2017; 1-6
• 21 Bramlett K, Onel E, Viscusi ER. et al. A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty. Knee 2012; 19: 530
• 22 Moradkhani MR, Karimi A, Negahdari B. Nanotechnology application to local anaesthesia (LA). Artif cells, nanomedicine, Biotechnol 2017; 1-6
• 23 Moradkhani MR, Karimi A, Negahdari B. et al. Drug anesthesia for children undergoing magnetic resonance imaging: A review. Biomed Pharmacother 2017; 88: 1183-1187
• 24 Baxter R, Bramlett K, Onel E. et al. Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies. Clin Ther 2013; 35: 312-320.e5
• 25 Tong YC, Kaye AD, Urman RD. Liposomal bupivacaine and clinical outcomes. Best Pract Res Clin Anaesthesiol 2014; 28: 15-27
• 26 White PF, SG AM. Analgesia following a single administration of depobupivacaine intraoperatively in patients undergoing inguinal herniorrhaphy: Preliminary dose-ranging studies. Anesth Analg 2009; 242:
• 27 Langford RM, CG KJ. A single administration of DepoBupivacaine intraoperatively results in prolonged detectable plasma bupivacaine and analgesia in patients undergoing inguinal hermia repair. Annu Postgrad Assem Anesthesiol New York State Soc Anesthesiol 2008; 9088:
• 28 Viscusi ER, Candiotti Ka, Onel E. et al. The pharmacokinetics and pharmacodynamics of liposome bupivacaine administered via a single epidural injection to healthy volunteers. Reg Anesth Pain Med 2012; 37: 616-622