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CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0044-1791958
Case Report

Follicular Dendritic Cell Sarcoma of the Thyroid Gland: A Rare Case Report

Mayadevi Poojari
1   Department of Radiation Oncology, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra, India
,
Irappa Madabhavi
2   Department of Medical and Pediatric Oncology and Hematology, J. N. Medical College, Belgaum, Karnataka, India
3   Kerudi Cancer Hospital, Bagalkot, Karnataka, India
4   Department of Medical and Pediatric Oncology and Hematology, Nanjappa Hospital, Shimoga, Karnataka, India
,
Jaydeep Pol
5   Department of Oncopathology, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra, India
,
Sharad Desai
6   Department of Surgical Oncology, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra, India
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Abstract

Introduction Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of antigen-presenting cells within the reticuloendothelial system primarily originating in lymph nodes, but in almost one-third of the patients, extranodal sites are involved including oral cavity, tonsil, gastrointestinal tract, soft tissue, and breast. The thyroid gland is an extremely rare location for FDCS and very few cases are reported in the literature.

Case Report Here, we present a 39-year-old man who presented with a swelling in the neck for 3 months and difficulty in breathing for 15 days. Following left hemi-thyroidectomy, histopathologically and immunohistologically, he was diagnosed as FDCS of thyroid arising in Castleman's disease. He received adjuvant radiation treatment. The patient had favorable prognosis with no evidence of disease for 6 years after treatment till date.

Conclusion The aim of this report was to present the rare site of FDCS arising in the thyroid gland, the vital role of immunohistochemistry in diagnosis, and effectiveness of multimodality treatment for favorable prognosis.

Keywords

follicular dendritic cell sarcoma - extranodal - thyroid - Castleman's disease - thyroidectomy - radiotherapy

Author Contributions

M.P., I.M., J.P., and S.D. conceived and designed the article, made critical revisions, and approved the final version. M.P. and I.M. collected data and literature and wrote the first draft of the manuscript. M.P., I.M., and J.P. contributed to the writing of the manuscript. M.P. and I.M. drew the tables. All authors reviewed and approved the final version of the manuscript.




Publication History

Received: 31 July 2024

Accepted: 21 September 2024

Article published online:
06 November 2024

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