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Synthesis 1987; 1987(3): 245-249
DOI: 10.1055/s-1987-27902
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PO-Activated Olefination and Conversion of Aldehydes and Ketones to Higher Amines; II. Synthesis of Arylethylamines

A. Heymes* , I. Chekroun
  • *Chemical Research Department, Sanofi (Sapchim), Route de Gap, F-04200 Sisteron, France
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Publication Date:
12 September 2002 (online)

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The transformation of arylcarboxaldehydes and/or - ketones 2 by three different routes into arylethylamines 3 and/or 4 is reported. According to the first route, the intermediate iminophosphonates 9 react through a classical PO-activated olefination. The second and the third involve the rearrangement of the iminophosphonates 9 into the vinylphosphoramidates 12.