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Synlett 1991; 1991(10): 695-696
DOI: 10.1055/s-1991-34760
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A Novel Approach to 6-Substituted 4-Pyridone-3-carboxylic Esters by Palladium-Catalyzed Carbonylative Coupling

Sigeru Torii* , Long He Xu, Hiroshi Okumoto
  • *Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima Naka, Okayama 700, Japan
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Publication Date:
13 March 2002 (online)

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A facile synthesis of the antibacterials, 6-substituted methyl 4-pyridone-3-carboxylates 4, has been accomplished through palladium-catalyzed carbonylative coupling of 2-bromo-3-aminoacrylates 1 with terminal acetylenes 2 followed by cyclization.