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Synlett 1991; 1991(10): 689-690
DOI: 10.1055/s-1991-34784
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Practical Asymmetric Synthesis of (R)-Fluoxetine Hydrochloride Catalyzed by (2S, 4S)-4-Dicyclohexylphosphino-2-diphenylphosphinomethyl-1-(N-methylcarbamoyl)pyrrolidine-Rhodium Complex1

Shunji Sakuraba* , Kazuo Achiwa
  • *School of Pharmaceutical Sciences, University of Shizuoka, 395 Yada, Shizuoka 422, Japan
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Publication Date:
13 March 2002 (online)

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The title complex, (2S,4S)-MCCPM-Rh(I) complex, was found to be an efficient catalyst for asymmetric hydrogenation of ß-amino ketone derivatives leading to a practical asymmetric synthesis of (R)-Fluoxetine [N-methyl-3-(4-trifluoromethylphenoxy)-3-phenylpropylamine] hydrochloride.