PDF herunterladen
Synthesis 1997; 1997(2): 165-167
DOI: 10.1055/s-1997-1169
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of exo-3-Hydroxy-7-azabicyclo[2.2.1]heptane-1-carboxylic Acid, a New Conformationally Constrained 4-Hydroxyproline

A. Avenoza1 , C. Cativiela2 , M. A. Fernández-Recio3 , J. M. Peregrina3
  • 1Department of Chemistry (Organic Chemistry). Edificio Científico-Técnico. Sección Ciencias. Universidad de La Rioja. 26001 Logroño, Spain, Fax +34(41)259431; E-mail alberto.avenoza@dq.unirioja.es
  • 2Department of Organic Chemistry. Instituto de Ciencia de Materiales de Aragón. Univesidad de Zaragoza-C.S.I.C. 50009 Zaragoza, Spain, Fax +34(76)761159; E-mail carlos.cativiela@msf.unizar.es
  • 3Department of Chemistry (Organic Chemistry). Edificio Científico-Técnico. Sección Ciencias. Universidad de La Rioja. 26001 Logroño, Spain
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

A conformationally constrained α-amino-β-hydroxy bases upon 4-hydroxyproline has been prepared, starting from an iodooxazine intermediate, by opening of the heterocycle, further intramolecular nucleophilic displacement and subsequent hydrolysis.

iodo-1,3-oxazine intermediate - intramolecular nucleophilic displacement - 4-hydroxyproline - 7-azabicyclo[2.2.1]heptane skeleton