PDF herunterladen
Synlett 1999; 1999(9): 1495-1507
DOI: 10.1055/s-1999-2865
new tools in synthesis
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Glycoprotein Synthesis: From Glycobiological Tools to Tailor-made Catalysts

Benjamin G. Davis* , J. Bryan Jones
  • *Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK; Fax + 44 191 3 84 47 37; E-mail: Ben.Davis@durham.ac.uk
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 1999 (online)

  als PDF herunterladen Lizenzen und Reprints Alle Artikel dieser Rubrik

The synthesis of pure, well-defined glycoproteins is essential to the study of the host of biological processes that they mediate. The use of a combined site-directed mutagenesis and chemical modification strategy allows the site-selective synthesis of homogeneous glycoproteins, the determination of precise structure-activity relationships and the design of new synthetic catalysts. This general and powerful method is reviewed in the context of existing preparative techniques and the wide-ranging applications of glycoproteins are highlighted

glycoproteins - carbohydrates - glycosylations - chemoselectivity - enzymes - biocatalysis