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Synthesis 2001; 2001(2): 0276-0280
DOI: 10.1055/s-2001-10815
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5-Isoxazolecarboxaldehyde: A Novel Substrate for Fast Baylis-Hillman Reaction

Arundhati Patra* , Sanjay Batra, Bijoy Kundu, Bhawani Shankar Joshi, Raja Roy, Amiya Prasad Bhaduri
  • *Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India; Fax +91(522)223405, +91(522)223938; E-mail: batra_san§yahoo.co.uk, root§cscdri.ren.nic.in
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Publikationsdatum:
31. Dezember 2001 (online)

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3-Aryl-5-isoxazolecarboxaldehyde undergoes fast Baylis-Hillman reaction with a variety of activated alkenes to yield the corresponding adducts in excellent yields. Some of the Baylis-Hillman adducts reported herein have been subsequently modified to obtain isoxazole substituted pyrazolin-3-ones and γ-butyrolactones.

5-isoxazolecarboxaldehyde - Baylis-Hillman reaction - pyrazolin-3-ones - HTIB - γ-butyrolactones