Cytotoxic Mono-Tetrahydrofuran Ring Acetogenins from Leaves of Annona montana

Abstract

Further studies on leaves of Annona montana led to isolation of one iso-acetogenin, montanacin G, three pairs of acetogenins, montanacin H-J and 34-epi-montanacin H-J, together with four known acetogenins, gigantetrocins A and B, annonacin and cis-annonacin. Montanacin G belongs to the iso-acetogenin group with a terminal 2,4-trans-ketolactone unit. Montanacin H-J and 34-epi-montanacin H-J contain the rare γ-hydroxy-γ-methyl-γ-lactone moiety. The cytotoxic activities of these compounds, together with previously reported acetogenins, montanacins B and C, were examined against Meth-A and LLC tumor cell lines in vitro.

Key words

Annona montana - Annonaceous acetogenins - montanacins G-J - 34-epi-monatanacins H-J - cytotoxic activity

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