Planta Med 2001; 67(9): 853-857
DOI: 10.1055/s-2001-18856
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Two New Steroidal Saponins from the Rhizomes of Dioscorea panthaica and their Cytotoxic Activity

Mei Dong2 , Xi-Zhi Feng2 , Li-Jun Wu2 , Ben-Xiang Wang1 , Takashi Ikejima1
  • 1 Research Center of New Drugs, Changchun College of Traditional Chinese Medicine, Changchun, People's Republic of China
  • 2 Department of Natural Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang, People's Republic of China
Further Information

Publication History

December 20, 2000

March 30, 2001

Publication Date:
06 December 2001 (online)

Abstract

Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-β-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-β-chacotrioside (4) and pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill. On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside and 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→ 4)]-β-D-glucopyranoside. These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner.

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Prof. Ben-Xiang Wang

Research Centre of New Drugs

Changchun College of Traditional Chinese Medicine

No. 20 Gongnong Main Road

Changchun, 130021

People's Republic of China

Email: cctcmwbx@public.cc.jl.cn

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