Planta Med 2002; 68(1): 79-81
DOI: 10.1055/s-2002-20057
Letter

© Georg Thieme Verlag Stuttgart · New York

The Skin-Lightening Effects of Artocarpin on UVB-Induced Pigmentation

Kuniyoshi Shimizu1 , Ryuichiro Kondo1 , Kokki Sakai1 , Norio Takeda2 , Tetsuji Nagahata2
  • 11 Department of Forestry and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
  • 22 Kansai Koso Co. Ltd., Ohnojo, Japan
Further Information

Publication History

December 28, 2000

June 30, 2001

Publication Date:
31 January 2002 (online)

Abstract

This study was conducted to evaluate the effects of the prenylated flavonol artocarpin from the heartwood of Artocarpus incisus on ultraviolet (UV)-induced hyperpigmentation of guinea pig skin. An efficient lightening effect was observed following topical application of artocarpin to UV-stimulated hyperpigmented dorsal skins of brownish guinea pigs.

References

  • 1 Hearing V J, Tsukamoto K. Enzymatic control of pigmentation in mammals.  FASEB Journal. 1991;  5 2902-9
  • 2 Shimizu K, Kondo R, Sakai K, Lee S -H, Sato H. The inhibitory components from Artocarpus incisus on melanin biosynthesis.  Planta Medica. 1998;  64 408-12
  • 3 Dooley T P. Topical skin depigmentation agents: current products and discovery of novel inhibitors of melanogenesis.  Journal of Dermatological Treatment. 1997;  8 275-9
  • 4 Sugai T. Clinical effects of arbutin in patients with chloasma (in Japanese).  Hifu (Skin Research). 1992;  34 522-9
  • 5 Mishima Y, Ohyama Y, Shibata T, Seto H, Hatae S. Inhibitory of kojic acid on melanogenesis and its therapeutic effect for various human hyper-pigmentation disorders (in Japanese).  Hifu (Skin Research). 1994;  36 134-50
  • 6 Sato M, Fujiwara S, Tsuchiya H, Fujii T, Iinuma M, Tosa H, Ohkawa Y. Flavones with antibacterial activity against cariogenic bacteria.  Journal of Ethnopharmacology. 1996;  54 171-6
  • 7 Yokota T, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation.  Pigment Cell Research. 1998;  11 355-61

Kuniyoshi Shimizu, PhD

Laboratory of Systematic Forest and Forest Products Science

Department of Forestry and Forest Products Sciences

Faculty of Agriculture

Kyushu University

6-10-1 Hakozaki, Higashi-ku

Fukuoka, 812-8581

Japan

Phone: +81-92-642-2991

Fax: +81-92-642-3078, +81-92-642-2990

Email: shimizu@agr.kyushu-u.ac.jp