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Synthesis 2003(4): 0551-0554
DOI: 10.1055/s-2003-37663
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Formylphenylpyridinecarboxylic Acids Using Suzuki-Miyaura Coupling Reactions

Peter Meier*, Stéphanie Legraverant, Sascha Müller, Josette Schaub
Novartis Institutes for Biomedical Research Basel/CT/CCU, Novartis Pharma AG, Lichtstrasse 35, 4056 Basel, Switzerland
Fax: +41(61)3244236; e-Mail: peter.meier@pharma.novartis.com;
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Publication History

Received 7 November 2002
Publication Date:
07 March 2003 (online)

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Abstract

Formylphenylboronic acids were coupled with bromopyridylcarboxylic acids in the presence of a palladium catalyst. The yields of the different biaryls are strongly dependant on the substitution pattern of the two coupling partners. The electronic and steric effects of these are discussed.

Key words

cross-coupling - palladium catalyst - biaryls - heterocycles - pyridine carboxylic acids

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