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Synlett 2004(2): 0380-0387
DOI: 10.1055/s-2003-44971
DOI: 10.1055/s-2003-44971
NEWTOOLS
© Georg Thieme Verlag Stuttgart · New York
Affinitychromic Polythiophenes: A Novel Bio-Photonic Tool for High-Throughput Screening and Diagnostics
Further Information
Received
12 September 2003
Publication Date:
04 December 2003 (online)
Publication History
Publication Date:
04 December 2003 (online)
Abstract
This article describes the thermochromic, ionochromic, and affinitychromic properties of various neutral conjugated polymers. These optical features based on a conformational modification of the conjugated backbone induced from side-chain order/disorder transition have led to interesting colorimetric and/or fluorimetric transducers for various chemosensor and biosensor applications. In particular, the recent development of cationic, water-soluble, chromic polythiophenes has allowed the easy, rapid, specific, and ultra-sensitive detection of various nucleic acids and proteins in aqueous media. Clearly, this new platform which combines variable triggers and an optical transducer should create a new generation of useful tools in the areas of diagnostics, therapeutics, and drug screening.
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1 Introduction
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2 Molecular and Structural Aspects of Chromic Polythiophenes
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3 Chemical and Biochemical Sensors
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3.1 Ionochromic Properties
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3.2 Affinitychromic Properties
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4 Conclusions and Perspectives
Key words
conjugated polymers - polythiophenes - biosensors - high-throughput screening - genomics
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