Abstract
This article describes the thermochromic, ionochromic, and affinitychromic properties
of various neutral conjugated polymers. These optical features based on a conformational
modification of the conjugated backbone induced from side-chain order/disorder transition
have led to interesting colorimetric and/or fluorimetric transducers for various chemosensor
and biosensor applications. In particular, the recent development of cationic, water-soluble,
chromic polythiophenes has allowed the easy, rapid, specific, and ultra-sensitive
detection of various nucleic acids and proteins in aqueous media. Clearly, this new
platform which combines variable triggers and an optical transducer should create
a new generation of useful tools in the areas of diagnostics, therapeutics, and drug
screening.
-
1 Introduction
-
2 Molecular and Structural Aspects of Chromic Polythiophenes
-
3 Chemical and Biochemical Sensors
-
3.1 Ionochromic Properties
-
3.2 Affinitychromic Properties
-
4 Conclusions and Perspectives
Key words
conjugated polymers - polythiophenes - biosensors - high-throughput screening - genomics
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