A Convenient Synthesis of Coumarins by Palladium(II)-Catalyzed Reaction of Phenols with Propiolic Acids

Masashi Kotani; Kiyomi Yamamoto; Juzo Oyamada; Yuzo Fujiwara; Tsugio Kitamura

doi:10.1055/s-2004-822360

PAPER

A Convenient Synthesis of Coumarins by Palladium(II)-Catalyzed Reaction of Phenols with Propiolic Acids

Masashi Kotani^a, Kiyomi Yamamoto^a, Juzo Oyamada^a, Yuzo Fujiwara^b, Tsugio Kitamura*^a
^a Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjo-machi, Saga 840-8502, Japan
Fax: +81(952)288548; e-Mail: kitamura@cc.saga-u.ac.jp;
^b Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Hakozaki, Fukuoka 812-8581, Japan

Abstract

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Abstract

A direct route to coumarin derivatives from phenols and propiolic acids has been developed. Phenols react with propiolic acids in the presence of Pd(OAc)₂ as a catalyst to give coumarins in good yields. The simple process occurs under mild conditions without any additives.

Key words

palladium - C-H activation - coumarins - phenols - propiolic acids

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References

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