Thorac Cardiovasc Surg 2007; 55(3): 177-179
DOI: 10.1055/s-2006-924625
Original Thoracic

© Georg Thieme Verlag KG Stuttgart · New York

Isolated Lung Perfusion with Paclitaxel and Docetaxel: Comparison of the Early Effects on Pulmonary Physiology

S. Tanju1 , B. Akpolat1 , E. Senturk2 , S. Ziyade1 , A. Toker1 , D. Yilmazbayhan3 , A. Aydiner4 , S. Dilege1
  • 1Thoracic Surgery, Istanbul Medical School, Istanbul University, Istanbul, Turkey
  • 2Anesthesiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
  • 3Pathology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
  • 4Medical Oncology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
Weitere Informationen

Publikationsverlauf

received June 5, 2006

Publikationsdatum:
05. April 2007 (online)

Abstract

Background: This study was designed to compare the early effects of docetaxel and paclitaxel on pulmonary physiology after isolated lung perfusion. Methods: Rats underwent isolated left lung perfusion with docetaxel in group 1 (n = 5), paclitaxel in group 2 (n = 5), and 0.9 %NaCl in the control group (n = 5). Ventilation pressures, compliance of the lungs, blood gas analysis and histopathological results were compared between the groups. Results: In group 1 and group 2, the decrease in PaO2 (p = 0.008) and increase in ventilation pressures were significantly higher than in the control group (p = 0.016). In group 2, pCO2 retention was higher compared to the docetaxel perfusion group (p = 0.016). In the histochemical assessment, intra-alveolar hemorrhage and mononuclear cell infiltration were dense and perivascular edema was not present in group 1. In group 2, perivascular and intraalveolar edema were found to be dense. Conclusion: Perfusion by either of the chemotherapeutics resulted in an alteration of lung physiology in rat lungs. If isolated lung perfusion is administered using chemotherapeutics from the taxanes group, it is suggested that docetaxel could be the first choice for isolated lung perfusion.

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MD Serhan Tanju

Thoracic Surgery
Istanbul Medical School
Istanbul University

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