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Synfacts 2006(6): 0558-0558
DOI: 10.1055/s-2006-934507
DOI: 10.1055/s-2006-934507
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Perhydroindolines by Ring-Opening/Ring-Closing Metathesis
Z. Liu, J. D. Rainier*
University of Utah, Salt Lake City, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Mai 2006 (online)
Significance
This constitutes the first report of a tandem stereoselective olefin ring-opening/ring-closing metathesis (RORCM) on 7-azanorbornenes yielding perhydroindoline derivatives in excellent yields. One of the intermediates, having the correct stereochemistry and functionality, was converted into derivatives exhibiting the required backbone of selected perhydroindoline-containing natural products, rostratins B-D (1-3).