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Synfacts 2006(9): 0868-0868  
DOI: 10.1055/s-2006-942043
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ageladine A

Contributor(s): Philip Kocienski
M. L. Meketa, S. M. Weinreb*
The Pennsylvania State University, University Park, USA
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Publication History

Publication Date:
23 August 2006 (online)

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Significance

Ageladine A is a nm inhibitor of matrixmetalloproteinases which are involved in the regulation of angiogenesis. Noteworthy steps in the synthesis depicted are (a) the 6π-azaelectrocyclization used to create the pyridine ring (C to D) and (b) the Suzuki-Miyaura coupling used to append the pyrrole ring (E to F).