Cycloartane Triterpene Glycosides from the Roots of Astragalus melanophrurius

ihsan Çaliş; Ayşen Yürüker; Deniz Taşdemir; Anthony D. Wright; Otto Sticher; Ying-De Luo; John M. Pezzuto

doi:10.1055/s-2006-957642

Planta Med 1997; 63(2): 183-186
DOI: 10.1055/s-2006-957642

Letters

Cycloartane Triterpene Glycosides from the Roots of Astragalus melanophrurius

ihsan Çaliş¹ , Ayşen Yürüker¹ , Deniz Taşdemir² , Anthony D. Wright² ^, ⁴ , Otto Sticher² , Ying-De Luo³ , John M. Pezzuto³

¹Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, TR-06100 Ankara, Turkey
²Department of Pharmacy, Swiss Federal Institute of Technology ETH Zurich, CH-8057 Zürich, Switzerland
³Program for Collaborative Research, College of Pharmacy, University of Illinois at Chicago, Chicago, U.S.A.
⁴Department of Pharmaceutical Biology, Technical University of Braunschweig, D-38106 Braunschweig, Germany

Abstract

als PDF herunterladen

Abstract

From the roots of Astragalus melanophrurius eight known saponins (1-8) were isolated. Based on spectral data (IR, ¹H- and ¹³C-NMR, and FABMS), the structures were established as astrasieversianins II (1) and X (4), astragalosides I (2), II (3), IV (5) and VI (7), and cyclocanthosides E (6) and G (8). The isolates were evaluated in a broad range of bioassay systems and found to be inactive. Modest antibacterial activity was observed, however, as was immunomodulatory activity, as indicated by stimulation of isolated human lymphocytes.

PDF (327 kb)