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Planta Med 1995; 61(1): 85-87
DOI: 10.1055/s-2006-958011
DOI: 10.1055/s-2006-958011
Letter
© Georg Thieme Verlag Stuttgart · New York
A Diterpene from Mikania obtusata Active on Trypanosoma cruzi
Further Information
Publication History
1994
1994
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199501/lookinside/thumbnails/10.1055-s-2006-958011-1.jpg)
Abstract
The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).