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Planta Med 1991; 57(1): 56-58
DOI: 10.1055/s-2006-960018
DOI: 10.1055/s-2006-960018
Papers
© Georg Thieme Verlag Stuttgart · New York
Platelet Aggregation Inhibitors from the Seeds of Swietenia mahagoni: Inhibition of in vitro and in vivo Platelet-Activating Factor-Induced Effects of Tetranortriterpenoids Related to Swietenine and Swietenolide
Weitere Informationen
Publikationsverlauf
1989
Publikationsdatum:
05. Januar 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199101/lookinside/thumbnails/10.1055-s-2006-960018-1.jpg)
Abstract
The ether extract from the seeds of Swietenia mahagoni Jacq. (Meliaceae) was found to inhibit platelet-activating factor (PAF)-induced platelet aggregation. Systematic separation of the extract afforded twenty eight tetranortriterpenoids related to swietenine and swietenolide. Among them, several new compounds, named swietemahonin A, D, E, and G and 3-O-acetylswietenolide and 6-O-acetylswietenolide, showed a strong inhibition against PAF-induced aggregation in vitro and in vivo assays.
Key words
Swietenia mahagoni - platelet-activating factor - platelet aggregation - tetranortriterpenoids - swietemahonin A, D, E, G, 3-O- and 6-O-acetyl-swietenolides