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DOI: 10.1055/s-2007-1012280
© Georg Thieme Verlag, Stuttgart · New York
VIP and Hormone Secretion from Thyroidal Follicular and C-Cells
Publikationsverlauf
1984
1985
Publikationsdatum:
14. März 2008 (online)
Summary
The effect of vasoactive intestinal peptide (VIP) on the cAMP system of the thyroid and on the secretion of T4 and T3 from the follicular cells and calcitonin and somatostatin from the C-cells was studied in perfused dog thyroid lobes. Activation of the cAMP system was evaluated by measurements of the amount of cAMP released into the perfusion medium. T4, T3, calcitonin and somatostatin were measured by radioimmunoassays. 3 × 10-6 M VIP induced increases in cAMP release and T4 and T3 secretion from the thyroid while there were no significant alterations in calcitonin and somatostatin release (n=4). In experiments employing both of the two isolated thyroid lobes 100 μU/ml TSH gave considerably higher increases in T4 and T3 secretion than 10-6 M VIP (n=4). The effect of 10-9M VIP on T4 and T3 secretion was similar to that of 10-6M VIP (n=4). 10-10M VIP induced a small but statistically significant increase in T4 and T3 secretion in two experiments while no effect was observed in two dogs.
This high sensitivity of the follicular cells to VIP and the demonstration by others of VIP containing nerves in the thyroid suggest that VIP-ergic nerves may be involved in the regulation of thyroid hormone secretion.
Key-Words
cAMP - Calcitonin - Somatostatin - Thyroxine - Triiodothyronine - Vasoactive Intestinal Peptide