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Horm Metab Res 1986; 18(4): 238-240
DOI: 10.1055/s-2007-1012282
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Morphine Induced Thyroxine Release from Rat Thyroid Gland In Vitro

E. Tal1 , Zs. Kovács, L. Korányi, E. Endröczi
  • Central Research Division, Postgraduate Medical School, Budapest, Hungary,
  • 1Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
Further Information

Publication History

1984

1985

Publication Date:
14 March 2008 (online)

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Summary

Male rat thyroid glands were incubated for two hours in Krebs-Ringer bicarbonate buffer with different amounts of morphine and/or naloxone. Five μg/ml morphine produced a significant increase in the T4 concentration of incubation medium, and resulted in an accumulation of cAMP in the tissue. Naloxone did not change the T4 release but its incubation with morphine prevented the morphine-induced changes. Similarly, naloxone inhibited the morphine-induced accumulation of cAMP in the thyroid tissue.

Key-Words

Morphine - Thyroxine - Thyroid Gland