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Endoscopy 1988; 20(6): 289-291
DOI: 10.1055/s-2007-1013023
© Georg Thieme Verlag KG Stuttgart · New York

Endoscopic Hemostasis by Local Injection of Epinephrine and Polidocanol in Bleeding Ulcer. A Prospective Randomized Trial

J. Balanzó, S. Sainz, J. Such, J. C. Espinós, C. Guarner, X. Cussó, J. Monés, F. Vilardell
  • Esouela de Patologia Digestiva, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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Publication History

Publication Date:
17 March 2008 (online)

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See also:

Extensive Necrosis of Gastric Mucosa Following Injection Therapy of Bleeding Peptic UlcerEndoscopy 1990; 22(06): 285-286
DOI: 10.1055/s-2007-1010728

See also:

Endoscopic Sclerosis in Bleeding Ulcers Can Results be Improved?Endoscopy 1989; 21(04): 196-196
DOI: 10.1055/s-2007-1012943

Summary

The present prospective randomized trial has been carried out to assess the efficacy of the endoscopic injection of epinephrine plus polidocanol, in the prompt treatment of upper gastrointestinal bleeding due to peptic lesions.

Over a period of one year, 72 patients were admitted to the study. Thirty-six of these underwent endoscopic treatment (group A), while the others received medical treatment (group B). Definitive hemostasis was achieved in 29 patients in group A, and in 21 in group B (p < 0.05). Seven patients in group A and 12 in group B underwent emergency surgery for persistent or recurrent bleeding (p = NS). Three patients from group B received endoscopic treatment owing to relative surgical contraindications. It was successful in all of them. Patients from group A needed a significantly lower number of units of packed red cells (p < 0.05).

Our results show that it is justified to employ endoscopic injection as the first therapeutic step in upper GI bleeding due to peptic gastroduoderal lesions.

Key words:

Endoscopic injection treatment - bleeding peptic ulcers