Anthracenic Derivatives from Psorospermum febrifugum and their in vitro Cytotoxicities to a Human Colon Carcinoma Cell Line1

Andrew Marston; Jean-Charles Chapuis; Bernard Sordat; Jerome D. Msonthi; Kurt Hostettmann

doi:10.1055/s-2007-969124

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Planta Med 1986; 52(3): 207-210
DOI: 10.1055/s-2007-969124

Full Papers

Anthracenic Derivatives from Psorospermum febrifugum and their in vitro Cytotoxicities to a Human Colon Carcinoma Cell Line¹

Andrew Marston² , Jean-Charles Chapuis² , Bernard Sordat³ , Jerome D. Msonthi⁴ , Kurt Hostettmann²

²Institut de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Université de Lausanne, CH-1005 Lausanne, Switzerland.
³Institut Suisse de Recherches Expérimentales sur le Cancer, CH-1066 Epalinges, Switzerland.
⁴Department of Chemistry, Chancellor College, University of Malaŵi, Zomba, Malaŵi.

1 Presented in part at the 33rd. Annual Congress on Medicinal Plant Research, Regensburg, F. R. G., 23-27 September, 1985.

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Publikationsverlauf

1985

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

Five anthranoid pigments, including a new anthraquinone and a new tetrahydroanthracene, were isolated from the root bark of Psorospermum febrifugum Spach (Guttiferae). Cytotoxic activity of these pigments against the human colon carcinoma cell line Co-115 was investigated. The tetrahydroanthracenes vismione D and acetylvismione D exerted reproducible cytotoxicity in this new in vitro test system.