Influence of Insulin Status on Extra-Mitochondrial Oxygen Metabolism in the Rat

J. G. Satav; K. R. Dave; S. S. Katyare

doi:10.1055/s-2007-978589

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Horm Metab Res 2000; 32(2): 57-61
DOI: 10.1055/s-2007-978589

Originals Clinical

Influence of Insulin Status on Extra-Mitochondrial Oxygen Metabolism in the Rat

J. G. Satav¹ , K. R. Dave² , S. S. Katyare²

¹Radiation Biology Division, Bhabha Atomic Research Center, Mumbai, India
²Department of Biochemistry, Faculty of Science, M. S. University of Baroda, Vadoclara, India

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Publication History

1999

1999

Publication Date:
19 April 2007 (online)

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The effects of alloxan diabetes and subsequent treatment with insulin on extra-mitochondrial oxygen metabolism in terms of D-amino acid oxidase (DAAO), xanthine oxidase and catalase were examined. The DAAO activity in the liver with Dalanine and D-serine decreased by 33-62% in the diabetic group while the decrease in the kidneys was 61-74%. Insulin treatment resulted in overstimulation of DAAO activity in the liver but not in the kidneys. Tissue glycogen content was lowered in the diabetic animals but was restored by insulin treatment. Tissue glycogen content and DAAO activity showed an inverse relationship. The xanthine oxidase activity in the two tissues decreased from 40-55%; the catalase activity decreased from 34-54%. Insulin treatment was unable to restore the xanthine oxidase and catalase activities in both the tissues.

Key words

Diabetes - Extra Mitochondrial Oxygen Metabolism - Xanthine Oxidase - Catalase - DAAO