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Pharmacopsychiatry 2007; 40: S62-S72
DOI: 10.1055/s-2007-992132
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Dopamine, Prefrontal Cortex and Working Memory Functioning in Schizophrenia

E. M. Meisenzahl 1 , J. Scheuerecker 1 , G. J. S. Schmitt 1 , H. J. Möller 1
  • 1Department of Psychiatry, Ludwig-Maximilians-University of Munich, Munich, Germany
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Publication History

Publication Date:
17 December 2007 (online)

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Abstract

Proposing working memory disturbances as one of the core symptoms of cognitive deficits in schizophrenia the authors summarize and discuss the dependency on prefrontal cortex functioning and working memory performance. On the basis of a strong association of prefrontal functioning and the dopaminergic system the authors refer to schizophrenia as an illustrative example. Altered dopamine function and associated working memory performance are discussed with regard to effects of psychopharmacological treatment to modulate cognitive processes.

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Correspondence

E.M. Meisenzahl

Department of Psychiatry

Ludwig-Maximilians-University of Munich

Nussbaumstrasse 7

80336 Munich

Germany

Phone: +49/89/5160 57 72

Fax: +49/89/5160 34 13

Email: Eva.Meisenzahl@med.uni-muenchen.de