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DOI: 10.1160/TH03-12-0784
Plasminogen activator inhibitor-1 and tumour growth, invasion, and metastasis
Financial support: The Danish Cancer Society, the Danish Research Agency, the Danish Cancer Research Foundation, the Novo-Nordisk Foundation and the Interdisciplinary Nanoscience Center at the University of Aarhus.Publikationsverlauf
Received
23. Dezember 2003
Accepted after revision
19. Januar 2004
Publikationsdatum:
05. Dezember 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200403/lookinside/thumbnails/10-1160-th03-12-0784-1.jpg)
Summary
In recent decades, evidence has been accumulating showing the important role of urokinase-type plasminogen activator (uPA) in growth, invasion, and metastasis of malignant tumours. The evidence comes from results with animal tumour models and from the observation that a high level of uPA in human tumours is associated with a poor patient prognosis. It therefore initially came as a surprise that a high tumour level of the uPA inhibitor plasminogen activator inhibitor-1 (PAI-1) is also associated with a poor prognosis, the PAI-1 level in fact being one of the most informative biochemical prognostic markers. We review here recent investigations into the possible tumour biological role of PAI-1, performed by animal tumour models, histological examination of human tumours, and new knowledge about the molecular interactions of PAI-1 possibly underlying its tumour biological functions. The exact tumour biological functions of PAI-1 remain uncertain but PAI-1 seems to be multifunctional as PAI-1 is expressed by multiple cell types and has multiple molecular interactions. The potential utilisation of PAI-1 as a target for anti-cancer therapy depends on further mapping of these functions.
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